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KMID : 0369820120420030109
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Jorunal of Korean Pharmaceutical Sciences
2012 Volume.42 No. 3 p.109 ~ p.114
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The feasibility study of transdermal drug delivery systems for antidepressants possessing hydrophilicity or hydrophobicity
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Baek Jong-Suep
Lim Ji-Ho
So Jae-Woo
Kim Jae-Il
Lee Tae-Wan
Hwang Sung-Joo
Shin Sang-Chul
Kim Soo-Jin
Cho Cheong-Weon
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Abstract
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The feasibility studies on the transdermal drug delivery systems have been performed to avoid the systemic side-effects and gastric disorders that could be occurred due to the transient high blood concentration after oral administration of antidepressants such as venlafaxine HCl and citalopram. When surfactants of tween 80® and plasticizer of diethyl phthalate were combined with citalopram?ethylene vinyl acetate (EVA) matrix, the permeation of citalopram showed the best enhancement. As well as, venlafaxine HCl gels were prepared using carbomer, oleic acid and/or propylene glycol to enhance the skin permeation of venlafaxine HCl. The citalopram-EVA matrix containing tween 80® and diethyl phthalate as permeation enhancers might be a good transdermal delivery system for providing sustained plasma concentrations of citalopram. Also, venlafaxine HCl showed the possibility to be enhanced skin permeation in the formulation of gels with carbomer including penetration enhancer, oleic acid and/or propylene glycol.
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KEYWORD
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Citalopram, Venlafaxine HCl, Antidepressants, Ethylene vinyl acetate, Penetration enhancer, Matrix, Gel, Pharmacokinetics
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